AI Article Synopsis
- The Tehran cardiometabolic genetic study (TCGS) is a large-scale research project involving 20,367 participants, aiming to understand non-communicable diseases that may arise in mid to late life.
- The study encompasses various health issues, including cardiovascular and metabolic disorders, cancers, and inherited diseases, while also monitoring health-related complications through detailed coding and self-reports since 2017.
- TCGS seeks to identify prevention and intervention targets for these diseases, providing insights to enhance precision medicine in public health.
Article Abstract
The Tehran cardiometabolic genetic study (TCGS) is a large population-based cohort study that conducts periodic follow-ups. TCGS has created a comprehensive database comprising 20,367 participants born between 1911 and 2015 selected from four main ongoing studies in a family-based longitudinal framework. The study's primary goal is to identify the potential targets for prevention and intervention for non-communicable diseases that may develop in mid-life and late life. TCGS cohort focuses on cardiovascular, endocrine, metabolic abnormalities, cancers, and some inherited diseases. Since 2017, the TCGS cohort has augmented by encoding all health-related complications, including hospitalization outcomes and self-reports according to ICD11 coding, and verifying consanguineous marriage using genetic markers. This research provides an update on the rationale and design of the study, summarizes its findings, and outlines the objectives for precision medicine.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175059 | PMC |
| http://dx.doi.org/10.1007/s10654-023-01008-1 | DOI Listing |
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