AI Article Synopsis
- Buckwheat can cause a rare condition called food protein-induced enterocolitis syndrome (FPIES), and this study focuses on a 4-year-old girl diagnosed with it.
- Standard allergy tests for IgE were negative, but a lymphocyte stimulation test showed significant activation in response to buckwheat.
- During an oral food challenge with buckwheat noodles, the patient experienced vomiting, confirming the diagnosis, and her lab results indicated inflammation, which might help in diagnosing similar non-IgE-mediated food allergies in the future.
Article Abstract
Buckwheat is a rare causative food for food protein-induced enterocolitis syndrome (FPIES). To date, it is unknown what laboratory data patients with FPIES caused by buckwheat show. We report a 4-year-old female with FPIES caused by buckwheat and the laboratory results. Skin prick, specific IgE antibody, and basophil activation tests were negative; however, the lymphocyte stimulation test (LST) revealed a 10.2-fold increase in activation compared with the negative control. In an open-label oral food challenge (OFC) of 80 g boiled buckwheat noodles, 3 hours after ingestion, vomiting occurred four times in a 2-hour duration. Therefore, we diagnosed the patient with FPIES caused by buckwheat. Her neutrophil count, C-reactive protein, and thymus and activation-regulated chemokine were elevated after the OFC. Moreover, the patient had a positive reaction to the LST, which may theoretically be useful in diagnosing non-immunoglobulin E-mediated gastrointestinal food allergies. FPIES caused by buckwheat is rare; however, we found that the same laboratory results were observed in a comparison of FPIES cases caused by other foods.
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| http://dx.doi.org/10.15586/aei.v51i3.826 | DOI Listing |
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