Background: There is evidence supporting the association between infection and colorectal cancer (CRC), but whether eradication reduces the risk of CRC is still unknown.
Objectives: To compare the incidence of CRC in subjects who had received eradication therapy with general population.
Design: A population-based retrospective cohort study.
Methods: This study included all -infected subjects who had received their first course of clarithromycin-containing triple therapy in 2003-2015 in Hong Kong. We compared the observed incidences of CRC in this eradicated cohort with the expected incidences in the age- and sex-matched general population. The standardized incidence ratio (SIR) with 95% confidence interval (CI) was computed.
Results: Among 96,572 -eradicated subjects with a median follow-up of 9.7 years, 1417 (1.5%) developed CRC. Primary analysis showed no significant difference in the observed and expected incidences of CRC (SIR: 1.03, 95% CI: 0.97-1.09). However, when stratified according to the follow-up period, higher incidence of CRC was only observed in the first 5 years after eradication (SIR: 1.47, 95% CI: 1.39-1.55), but it was lower (SIR: 0.85, 95% CI: 0.74-0.99) than general population after 11 years. When stratified by tumor location, the observed incidence was higher for colon (SIR: 1.20, 95% CI: 1.12-1.29) but lower for rectal cancer (SIR: 0.90, 95% CI: 0.81-0.999) among -eradicated subjects.
Conclusions: -infected subjects appeared to have a higher incidence of CRC initially, which declined progressively to a level lower than general population 10 years after eradication, particularly for rectal cancer.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164860 | PMC |
http://dx.doi.org/10.1177/17562848231170943 | DOI Listing |
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