Four-part harmony between diet, drugs, microbes, and host.

Cell Host Microbe

Department of Microbiology, The Ohio State University, Columbus, OH 43201, USA; Infectious Diseases Institute, The Ohio State University, Columbus, OH 43201, USA. Electronic address:

Published: May 2023

In this issue of Cell Host & Microbe, Zeng et al. show that a specific gut microbe causes diet-dependent attenuation of acetaminophen toxicity in mice. This link between gut microbes and toxicity is mechanistically detailed, yet intriguingly indirect, mediated by the transformation of ingested phytochemicals as opposed to the drug itself.

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http://dx.doi.org/10.1016/j.chom.2023.04.013DOI Listing

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