Taste vs. pain: A sensory feast in bacterial meningitis.

Cell Host Microbe

Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA. Electronic address:

Published: May 2023

During meningitis, sensory neurons detect bacterial toxins and metabolites. Early activation of pain receptors suppresses host defense in the meninges while, later, taste receptors amplify inflammation in the spinal cord. Is a neuroimmune axis a clue to new treatments?

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http://dx.doi.org/10.1016/j.chom.2023.04.006DOI Listing

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