Two fluorescent sensors with the receptor semicarbazide respectively at 7- (CAA) and 3-position (CAB) of coumarin were designed and synthesized. CAA exhibits fluorescence turn-on response to Cu by triggering the intramolecular charge transfer (ICT) process via Cu-catalyzed hydrolysis, and can detect formaldehyde (FA) at different channel by inhibiting the photo-induced electron transfer (PET). However, CAB displays quite different responses: the photophysical properties hardly changed in the presence of FA; while a three-stage fluorescence response of fast quenching, steady increasing and slowly decreasing was found upon addition of Cu. The high selectivity enabled CAA a good candidate for quantification of Cu and formaldehyde as well as bioimaging Cu in living cells. Good linear relationships between the fluorescence intensity and analyte concentration were observed in the range of 0.1-30 μM for Cu and 1.0-50 μM for FA, and their detection limits (LOD) were calculated to be 0.43 μM and 1.92 μM (3δ/k), respectively.
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| http://dx.doi.org/10.1016/j.saa.2023.122818 | DOI Listing |
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