Medically Attended Acute Adverse Events in Pregnant People After Coronavirus Disease 2019 (COVID-19) Booster Vaccination.

Obstet Gynecol

HealthPartners Institute, Bloomington, Minnesota; the Marshfield Clinic Research Institute, Marshfield, Wisconsin; the Harvard Pilgrim Health Care Institute, Boston, Massachusetts; the Institute for Health Research, Kaiser Permanente Colorado, and Ambulatory Care Services and the Center for Health Systems Research, Denver Health, Denver, Colorado; Kaiser Permanente Southern California, Pasadena, and the Kaiser Permanente Vaccine Study Center, Oakland, California; Weill Cornell-Medicine, New York, New York; the Kaiser Permanente Center for Health Research, Portland, Oregon; Kaiser Permanente Washington, Seattle, Washington; and the Immunization Safety Office, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia.

Published: July 2023

AI Article Synopsis

  • A study involving over 80,000 pregnant individuals found that receiving a COVID-19 mRNA booster shot did not increase the risk of serious health issues like thrombocytopenia, myocarditis, or stroke shortly after vaccination.
  • However, the booster was linked to a higher incidence of mild symptoms such as malaise or fatigue within the first week, and lymph node swelling or inflammation in the following weeks.
  • Overall, the results align with previous studies and suggest that it's safe for pregnant people to receive the COVID-19 booster.

Article Abstract

In this multisite, observational, matched cohort study of more than 80,000 pregnant people, receipt of an mRNA monovalent coronavirus disease 2019 (COVID-19) booster vaccination in pregnancy was not associated with increased risk for thrombocytopenia, myocarditis, venous thromboembolism, ischemic stroke, or other serious adverse events within 21 or 42 days after booster vaccination. The mRNA monovalent COVID-19 booster in pregnancy was associated with an increased risk for medically attended malaise or fatigue within 7 days of vaccination (adjusted rate ratio [aRR] 3.64, 95% CI 2.42-5.48) and lymphadenopathy or lymphadenitis within 21 days (aRR 3.25, 95% CI 1.67-6.30) or 42 days (aRR 2.18, 95% CI 1.33-3.58) of vaccination. Our findings are consistent with prior evaluations of the primary COVID-19 vaccine series and are reassuring with respect to COVID-19 booster vaccination in pregnancy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10278564PMC
http://dx.doi.org/10.1097/AOG.0000000000005241DOI Listing

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