We have developed a mild sulfenylation of pyrrolo[2,1-]isoquinolines with acetyl bromide and dimethyl sulfoxide. A wide range of functionalized pyrrolo[2,1-]isoquinolines could be prepared efficiently through the formation of a C-S bond with thiophenols (27 examples, 36-94% yields). The current strategy can also be utilized for functionalization of pyrrolo[1,2-]quinolines and indole.
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| http://dx.doi.org/10.1021/acs.joc.3c00566 | DOI Listing |
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