The acute thrombogenicity of a new type of polyurethane urea graft was compared with that of autologous femoral vein graft in a sheep carotid artery interposition model. There was significantly more thrombus formation (as measured from thrombus weight and thrombus-free surface) and greater platelet accumulation in the polyurethane graft. Despite flow restriction to 25 ml/min, the patency rates after 4 hours were similar; all veins were patent and only one of the eight polyurethane grafts was occluded.
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