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| http://dx.doi.org/10.1007/s10995-023-03674-9 | DOI Listing |
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Orthogonal and multiplexable genetic perturbations with an engineered prime editor and a diverse RNA array.
Nat Commun
December 2024
Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, USA.
Programmable and modular systems capable of orthogonal genomic and transcriptomic perturbations are crucial for biological research and treating human genetic diseases. Here, we present the minimal versatile genetic perturbation technology (mvGPT), a flexible toolkit designed for simultaneous and orthogonal gene editing, activation, and repression in human cells. The mvGPT combines an engineered compact prime editor (PE), a fusion activator MS2-p65-HSF1 (MPH), and a drive-and-process multiplex array that produces RNAs tailored to different types of genetic perturbation.
View Article and Find Full Text PDFCase Report: Avoiding misdiagnosis in amyloidosis-navigating transthyretin genopositivity and monoclonal gammopathy in a patient with advanced heart failure and spinal stenosis.
Front Cardiovasc Med
December 2024
Division of Hematology-Oncology, Department of Medicine, Tufts Medical Center, Boston, MA, United States.
Background: A 63-year-old Black woman presented with progressive exertional dyspnea and chronic lower back pain. The course and findings in her case are instructive.
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Knowledge and attitudes of primary care physicians regarding acromegaly: a survey study with multinational participation.
BMC Prim Care
December 2024
Department of Internal Medicine, Division of Endocrinology and Metabolism, Cerrahpasa Medical Faculty, Istanbul University Cerrahpasa, Istanbul, Turkey.
Background: Acromegaly is a disease with high morbidity and mortality rates. The role of primary care physicians is very important in the early diagnosis of acromegaly. The present study aims to determine the knowledge and attitudes of primary care physicians about acromegaly in different countries worldwide.
View Article and Find Full Text PDFRelationship Between Physical Exercise and Risk of Depression: An Assessment of Intermediate Variables Through Self-Assessed Health Status and Life Satisfaction in the Chinese Family Tracking Survey (CFPS) Data.
Risk Manag Healthc Policy
December 2024
School of Physical Education, Huaibei Normal University, Huaibei, People's Republic of China.
Objective: Depression is a potential health killer. As an important means of preventing various human diseases, physical exercise plays an important role in reducing the risk of depression. Using data from the Chinese Household Tracking Survey, this study analyzed the mechanisms by which physical exercise, self-rated health and life satisfaction reduce the risk of depression.
View Article and Find Full Text PDFCoCoNest: A continuous structural connectivity-based nested family of parcellations of the human cerebral cortex.
Netw Neurosci
December 2024
Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Despite the widespread exploration and availability of parcellations for the functional connectome, parcellations designed for the structural connectome are comparatively limited. Current research suggests that there may be no single "correct" parcellation and that the human brain is intrinsically a multiresolution entity. In this work, we propose the Continuous Structural Connectivitity-based, Nested (CoCoNest) family of parcellations-a fully data-driven, multiresolution family of parcellations derived from structural connectome data.
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