An efficient method for C()-CHF bond formation was successfully developed by copper-catalyzed cross-coupling of allyl phosphate with 2-fluoro-2-(trimethylsilyl)acetate. Under moderate circumstances, the conversion was carried out in a good strategic range to provide a series of monofluoroalkylation products in high yields, which also demonstrates the practicality of gram-scale reactions.
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Asymmetric copper-catalyzed alkynylallylic monofluoroalkylations with fluorinated malonates.
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Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China.
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School of Chemistry and Chemical Engineering, Hefei University of Technology, 193 Tunxi Road, Anhui 230009, China.
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Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui, 230026, China.
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