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Water is the basic molecule in living beings, and it has a major impact on vital processes. Plants are sessile organisms with a sophisticated regulatory network that regulates how resources are distributed between developmental and adaptation processes. Drought-stressed plants can change their survival strategies to adapt to this unfavorable situation.
View Article and Find Full Text PDFPrognostic impact of next-generation sequencing on myelodysplastic syndrome: A single-center experience.
Medicine (Baltimore)
October 2024
Hematology Department, İzmir City Hospital, Bayrakli/İzmir, Turkey.
Article Synopsis
- * Recent studies utilizing next-generation sequencing (NGS) have identified numerous genetic abnormalities in patients with MDS, revealing mutations in 21 different genes that could correlate with disease characteristics and clinical outcomes.
- * Findings suggest that certain non-SF3B1 mutations are associated with worse clinical indicators, such as thrombocytopenia and decreased overall survival, indicating that NGS could play a crucial role in future prognostics for MDS, even in patients with normal cytogenetics.
Structure and evolution of metapolycentromeres.
Vavilovskii Zhurnal Genet Selektsii
October 2024
Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Metapolycentromeres consist of multiple sequential domains of centromeric chromatin associated with a centromere-specific variant of histone H3 (CENP-A), functioning collectively as a single centromere. To date, they have been revealed in nine flowering plant, five insect and six vertebrate species. In this paper, we focus on their structure and possible mechanisms of emergence and evolution.
View Article and Find Full Text PDFEditorial: The clinical utility of long read sequencing to improve diagnostic yield and uncover biological mechanisms in rare disease.
Front Genet
October 2024
Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, University of Milan, Milan, Italy.
Host repair polymorphisms and H. pylori genes in gastric disease outcomes: Who are the guardian and villains?
Gene
January 2025
Federal University of Ceará, Department of Pathology and Forensic Medicine, Coronel Nunes de Melo Street, 1315, Rodolfo Teófilo, Fortaleza, Ceará, Brazil. Electronic address:
Gastric cancer (GC) is the fourth-leading cause of cancer-related mortality. The intestinal subtype of GC comes after the cascade of Correa, presenting H. pylori infection as the major etiological factor.
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