Develop and analyze triple-negative breast cancer targeted nanoparticles loaded with the demethylating agent decitabine. The polymers were synthesized by ring-opening polymerization of D,L-lactide and formulated into nanoparticles via emulsion-evaporation method. The nanoparticles were characterized by physicochemical analysis as well as using breast cancer cell lineages. The targeted nanoparticles exhibited a hydrodynamic diameter of 75 ± 12 nm, zeta potential -6.3 ± 0.2 mV and spherical morphology, and displayed greater accumulation into MDA-MB-231 (triple-negative breast cancer cell-line) compared with MCF7 and HB4A cell lineages as verified by fluorescence confocal microscopy and significant demethylating effects via screening by PCR.
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| http://dx.doi.org/10.2217/nnm-2023-0006 | DOI Listing |
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