Due to the boom of Internet of Things (IoT) in recent years, various IoT devices are connected to the Internet and communicate with each other through network protocols such as the Constrained Application Protocol (CoAP). These protocols are typically defined and described in specification documents, such as Request for Comments (RFC), which are written in natural or semi-formal languages. Since developers largely follow the specification documents when implementing web protocols, they have become the de facto protocol specifications. Therefore, it must be ensured that the descriptions in them are consistent to avoid technological issues, incompatibility, security risks, or even legal concerns. In this work, we propose Neural RFC Knowledge Graph (NRFCKG), a neural network-generated knowledge graph based contradictions detection tool for IoT protocol specification documents. Our approach can automatically parse the specification documents and construct knowledge graphs from them through entity extraction, relation extraction, and rule extraction with large language models. It then conducts an intra-entity and inter-entity contradiction detection over the generated knowledge graph. We implement NRFCKG and apply it to the most extensively used messaging protocols in IoT, including the main RFC (RFC7252) of CoAP, the specification document of MQTT, and the specification document of AMQP. Our evaluation shows that NRFCKG generalizes well to other specification documents and it manages to detect contradictions from these IoT protocol specification documents.
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http://dx.doi.org/10.1016/j.isatra.2023.04.025 | DOI Listing |
Cureus
December 2024
Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, JPN.
This case study details a 41-year-old male patient with Freeman-Sheldon syndrome (FSS) who presented with ocular hypertension. The intraocular pressure (IOP) in his right eye progressively increased over time, leading to visual field loss, culminating in a diagnosis of juvenile-onset open-angle glaucoma (JOAG). Despite conventional medical therapies, adequate IOP control was not achieved, necessitating his referral to Nagoya City University Hospital.
View Article and Find Full Text PDFCurr Res Toxicol
December 2024
Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Ectopic lipid deposition in the hepatocyte plays an important role in the development of nonalcoholic fatty liver disease (NAFLD), which has become one of the most common causes of chronic liver disease worldwide yet no approved drugs are currently available. In this study, a cell-based method was developed to screen potential drugs with low toxicity that inhibit lipid accumulation. In the same 96-well plate, cytotoxicity was measured using CCK8 assay, followed by lipid content detection using BODIPY 493/503 via fluorometry assay, a lipid droplet-specific fluorescent dye commonly used in microscopy and flow cytometry, but not previously reported in fluorometry.
View Article and Find Full Text PDFFront Hum Neurosci
January 2025
Infection and Global Health Division, School of Medicine, University of St Andrews, St Andrews, United Kingdom.
These case studies explore the subjective visual experiences of individuals with cerebral visual impairment (CVI), specifically dorsal stream dysfunction (DSD) characterized by simultanagnosia. Through three in-depth case studies, this work documents the challenges these individuals face when navigating cluttered environments. The individuals were asked to describe their visual experiences while watching videos of varying complexity, with the future aim of creating a simulation of simultanagnosia.
View Article and Find Full Text PDFDisabil Rehabil
January 2025
School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Purpose: This study aimed to i) identify child and family goals reported in a community allied health service, ii) map goals to ICF domains, and iii) evaluate goal characteristics against child-centred and family-centred practice principles.
Methods: A retrospective study design was used to extract and analyse raw goal data documented for children and families accessing a community-based allied health service. ICF linking rules were used to map goals to the ICF domains.
BMC Pharmacol Toxicol
January 2025
Clinical Research Unit, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Interleukin-23 (IL-23) inhibitors and the IL-12/23 inhibitor ustekinumab constitute a pivotal class of therapeutic agents employed in the clinical management of Psoriasis, a chronic immune-mediated skin disorder. Notwithstanding their therapeutic efficacy, concerns have arisen due to the emergence of multiple adverse events (AEs) associated with their usage. This study aims to provide a comprehensive examination of the distribution and characteristics of these AEs concerning IL-23 and IL-12/23 inhibitors, with a specific focus on guselkumab, tildrakizumab, risankizumab, and ustekinumab.
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