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College of Pharmacy, Korea University, Sejong 30019, Republic of Korea.
Published: July 2023
AI Article Synopsis
* The ethanol extract from DC. var. Pit. significantly reduced nitric oxide levels in vitro, and researchers identified 11 compounds, including a new one named gouanioside A.
* The study suggests that gouanioside A could be a potential treatment for inflammatory diseases, as it affects nitric oxide synthesis in immune cells.
Article Abstract
Metabolites from medicinal plants continue to hold significant value in the exploration and advancement of novel pharmaceuticals. In the search for plants containing compounds with anti-inflammatory effects, we observed that the ethanol (EtOH) extract obtained from the aerial components of DC. var. Pit. exhibited substantial suppression of nitric oxide (NO) in vitro. In a phytochemical study on an EtOH extract of , 11 compounds were purified, including one unreported compound namely gouanioside A (1). Their chemical structures were unambiguously determined through the use of various spectroscopic techniques, such as 1 and 2D NMR, IR, and HR-ESI-MS, and by producing derivatives via chemical reactions. The EtOH extract, fractions, and a new compound exerted inflammatory effects by altering NO synthesis in murine RAW264.7 macrophage cells stimulated with lipopolysaccharide. The underlying inflammatory mechanism of the new compound 1 was also explored through various in vitro experiments. The results of this study indicate the potential usefulness of new compound 1 from as a treatment for inflammatory diseases.
