Paeonol, the active component of Cynanchum paniculatum, ameliorated schizophrenia-like behaviors by regulating the PI3K-Akt-GSK3β-NF-κB signalling pathway in MK-801-treated mice.

J Ethnopharmacol

Agriculture and Life Science Research Institute, Kangwon National University, Chuncheon, 24341, Republic of Korea; Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341, Republic of Korea; School of Natural Resources and Environmental Sciences, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address:

Published: October 2023

AI Article Synopsis

  • Cynanchum paniculatum has a history of use in East Asia for its pain-relieving and antiviral properties, and traditional texts indicate potential benefits for treating psychotic symptoms like hallucinations and delusions.
  • The study investigated the effects of C. paniculatum and its main compound, paeonol, on mice with schizophrenia-like behaviors induced by MK-801, finding that paeonol may help alleviate symptoms.
  • Results showed that both C. paniculatum extract and paeonol improved sensorimotor gating and cognitive deficits in the mice, suggesting paeonol could be a promising treatment for schizophrenia-related issues.

Article Abstract

Ethnopharmacological Relevance: Cynanchum paniculatum (Bunge) Kitag. ex H. Hara (Asclepiadaceae) have been traditionally used in East Asia as analgesic or antiviral agents. Interestingly, some Chinese and Korean traditional medicinal books reported that the use of C. paniculatum in the treatment of psychotic symptoms, such as hallucinations and delusions.

Aim Of The Study: In this study, we aimed to investigate whether C. paniculatum could improve sensorimotor gating disruption in mice with MK-801-induced schizophrenia-like behaviors. We also aimed to identify the active component of C. paniculatum that could potentially serve as a treatment for schizophrenia and found that paeonol, the major constituent compound of C. paniculatum, showed potential as a treatment for schizophrenia.

Materials And Methods: To assess the effect of paeonol on mice with MK-801-induced schizophrenia-like behaviors, we carried out a series of behavioral tests related with symptoms of schizophrenia. In addition, we utilized Western blotting and ELISA techniques to investigate the antipsychotic actions of paeonol.

Result: C. paniculatum extract (100 or 300 mg/kg) and paenol (10 or 30 mg/kg) significantly reversed MK-801-induced prepulse deficits in acoustic startle response test. In addition, paeonol (10 or 30 mg/kg) attenuated social novelty preference and novel object recognition memory on MK-801-induced schizophrenia-like behaviour in mice. Furthermore, the phosphorylation levels of PI3K, Akt, GSK3β and NF-κB, as well as related pro-inflammatory cytokine, such as IL-1β and TNF-α, were significantly reversed by the administration of paeonol (10 or 30 mg/kg) in the prefrontal cortex of MK-801-treated mice.

Conclusions: Collectively, these data show that paeonol can potentially be used as an agent for treating sensorimotor gating deficits, negative symptoms, and cognitive deficits, such as those observed in schizophrenia with few adverse effects.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2023.116627DOI Listing

Publication Analysis

Top Keywords

schizophrenia-like behaviors
12
mk-801-induced schizophrenia-like
12
active component
8
cynanchum paniculatum
8
sensorimotor gating
8
mice mk-801-induced
8
paeonol 30 mg/kg
8
paniculatum
7
paeonol
6
paeonol active
4

Similar Publications

Hippocampal reelin and GAD67 gene expression and methylation in the GFAP.HMOX1 mouse model of schizophrenia.

Biochim Biophys Acta Mol Cell Res

January 2025

Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada. Electronic address:

Schizophrenia is a complex neuropsychiatric disorder featuring enhanced brain oxidative stress and deficient reelin protein. GFAP.HMOX1 mice that overexpress heme oxygenase-1 (HO-1) in astrocytes manifest a schizophrenia-like neurochemical, neuropathological and behavioral phenotype including brain oxidative stress and reelin downregulation.

View Article and Find Full Text PDF

Fragile X autosomal homolog 1 (FXR1), a member of the fragile X messenger riboprotein 1 family, has been linked to psychiatric disorders including autism and schizophrenia. Parvalbumin (PV) interneurons play critical roles in cortical processing and have been implicated in FXR1-linked mental illnesses. Targeted deletion of FXR1 from PV interneurons in mice has been shown to alter cortical excitability and elicit schizophrenia-like behavior.

View Article and Find Full Text PDF

Clozapine and rapamycin reverse behavioral abnormalities in an animal model of autoimmune schizophrenia.

Neuropharmacology

December 2024

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; Neuroscience Center, Chinese Academy of Medical Sciences, Beijing, China. Electronic address:

Objective: Autoantibody-associated psychosis represents a distinct disease subgroup of patients with schizophrenia with a suspected autoimmune origin. Although preliminary studies have suggested adjunctive drug treatment strategies targeting the immune system, further validation of these findings is warranted. Autoantibodies against SFT2D2 have been identified in patients with schizophrenia.

View Article and Find Full Text PDF

Lutein Exerts Antioxidant and Neuroprotective Role on Schizophrenia-Like Behaviours in Mice.

Int J Dev Neurosci

February 2025

Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Schizophrenia is an esteemed neuropsychiatric condition delineated by the manifestation which role of the N-methyl-D-aspartate receptor (NMDAR) is important. Lutein administration exhibits protective effects via NMDA receptors. Thus, the main goal of this research was to investigate how lutein can possibly act as an antioxidant and provide protection for the brain against schizophrenia-like behaviours in mice.

View Article and Find Full Text PDF

Schizophrenia is a kind of neurodevelopmental mental disorder in which patients begin to experience changes early in their development, typically manifesting around or after puberty and has a fluctuating course. Environmental disturbances during adolescence may be a risk factor for schizophrenia-like deficits. As a better treatment option, preventive intervention prior to schizophrenia may be more beneficial than direct treatment.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!