Different across-layer synchronization types of chimera states in multilayer networks have been discovered recently. We investigate possible relations between them, for example, if the onset of some synchronization type implies the onset of some other type. For this purpose, we use a two-layer network with multiplex inter-layer coupling. Each layer consists of a ring of non-locally coupled phase oscillators. While oscillators in each layer are identical, the layers are made non-identical by introducing mismatches in the oscillators' mean frequencies and phase lag parameters of the intra-layer coupling. We use different metrics to quantify the degree of various across-layer synchronization types. These include phase-locking between individual interacting oscillators, amplitude and phase synchronization between the order parameters of each layer, generalized synchronization between the driver and response layer, and the alignment of the incoherent oscillator groups' position on the two rings. For positive phase lag parameter mismatches, we get a cascaded onset of synchronization upon a gradual increase of the inter-layer coupling strength. For example, the two order parameters show phase synchronization before any of the interacting oscillator pairs does. For negative mismatches, most synchronization types have their onset in a narrow range of the coupling strength. Weaker couplings can destabilize chimera states in the response layer toward an almost fully coherent or fully incoherent motion. Finally, in the absence of a phase lag mismatch, sufficient coupling turns the response dynamics into a replica of the driver dynamics with the phases of all oscillators shifted by a constant lag.
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J Med Chem
January 2025
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
The tedious synthesis and limited throughput biological evaluation remain a great challenge for discovering new proteolysis targeting chimera (PROTAC). To rapidly identify potential PROTAC lead compounds, we report a platform named Auto-RapTAC. Based on the modular characteristic of the PROTAC molecule, a streamlined workflow that integrates lab automation with "click chemistry" joint building-block libraries was constructed.
View Article and Find Full Text PDFACS Chem Biol
January 2025
Institut für Pharmazeutische Chemie, Goethe-University Frankfurt, Biozentrum, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Small molecule degraders such as PROteolysis TArgeting Chimeras (PROTACs) and molecular glues are new modalities for drug development and important tools for target validation. When appropriately optimized, both modalities lead to proteasomal degradation of the protein of interest (POI). Due to the complexity of the induced multistep degradation process, controls for degrader evaluation are critical and commonly used in the literature.
View Article and Find Full Text PDFPhys Life Rev
December 2024
Community Healthcare Center Dr. Adolf Drolc Maribor, Ulica talcev 9, 2000 Maribor, Slovenia; Faculty of Natural Sciences and Mathematics, University of Maribor, Koroška cesta 160, 2000 Maribor, Slovenia; Complexity Science Hub, Metternichgasse 8, 1080 Vienna, Austria; Department of Physics, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. Electronic address:
Synchrony in neuronal networks is crucial for cognitive functions, motor coordination, and various neurological disorders. While traditional research has focused on pairwise interactions between neurons, recent studies highlight the importance of higher-order interactions involving multiple neurons. Both types of interactions lead to complex synchronous spatiotemporal patterns, including the fascinating phenomenon of chimera states, where synchronized and desynchronized neuronal activity coexist.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
New Cornerstone Science Laboratory, MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou 350108, People's Republic of China.
Proteolysis-targeting chimeras (PROTACs) are dual-functional molecules composed of a protein of interest (POI) ligand and an E3 ligase ligand connected by a linker, which can recruit POI and E3 ligases simultaneously, thereby inducing the degradation of POI and showing great potential in disease treatment. A challenge in developing PROTACs is the design of linkers and the modification of ligands to establish a multifunctional platform that enhances degradation efficiency and antitumor activity. As a programmable and modifiable nanomaterial, DNA tetrahedron can precisely assemble and selectively recognize molecules and flexibly adjust the distance between molecules, making them ideal linkers.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Physiology, Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
Spinal cord injury (SCI) leads to permanent motor and sensory loss that is exacerbated by intraspinal inflammation and persists months to years after injury. After SCI, monocyte-derived macrophages (MDMs) infiltrate the lesion to aid in myelin-rich debris clearance. During debris clearance, MDMs adopt a proinflammatory phenotype that exacerbates neurodegeneration and hinders recovery.
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