AI Article Synopsis
- A new chemical reaction has been developed that uses a Lewis base to create a specific type of compound through a formal [4 + 2] annulation process.
- The reaction combines acylamino-aryl MBH carbonates with electron-deficient olefins, resulting in the formation of tetrahydroquinolines.
- These tetrahydroquinolines have three stereogenic centers, including a quaternary stereocenter, and are produced in high yields with good enantioselectivity.
Article Abstract
The Lewis-base-catalyzed enantioselective formal [4 + 2] annulation reaction of -acylamino-aryl MBH carbonates and electron-deficient olefins was developed. Tetrahydroquinolines with three sequential stereogenic centers containing a quaternary stereocenter were obtained in high yields with good enantioselectivity.
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| http://dx.doi.org/10.1021/acs.orglett.3c00525 | DOI Listing |
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