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Optimization and Evaluation of -Based Magistral Formulations: A Path to Personalized Therapy.
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January 2025
Department of Drug Form Technology, Wroclaw Medical University, Borowska 211 A, 50-556 Wroclaw, Poland.
Introduction: The official implementation of pharmaceutical-grade cannabis raw materials for medicinal use has permitted doctors to prescribe and pharmacists to prepare cannabis-based formulations. The objective of the pharmaceutical development and manufacturing process optimization work was to propose a suppository formulation containing doses of 25 mg and 50 mg of tetra-hydrocannabinol (∆-9-THC) as an alternative to existing inhalable or orally administered formulations. The formulation could be used for rectal or vaginal administration, thereby providing dosage control in the treatment of endometriosis and other conditions involving pain.
View Article and Find Full Text PDFA framework for understanding the path to achieve high resilience of maritime supply chain.
Sci Rep
January 2025
College of Navigation, Jimei University, Xiamen, 361021, Fujian, China.
In recent years, a significant rise in international sudden risk events has resulted in impacts and disruptions to maritime supply chains (MSC). The resilience of maritime supply chains has garnered attention from the academic, industrial, and government sectors. The paper proposes a methodological framework based on the structural equation model (SEM), Necessary Condition Analysis (NCA), fuzzy set qualitative comparative analysis (fsQCA), and utilizes questionnaire data from the maritime industry in China to evaluate the resilience in MSC.
View Article and Find Full Text PDFCollege major decision making behavior of urban and rural students under cultural capital impact in China.
Sci Rep
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School of Education, Shanghai Jiao Tong University, Shanghai, China.
Academic major selection is a critical decision-making process influenced by various socioeconomic factors. This study investigates the behavioral patterns in educational choices, focusing on the impact of urban-rural background and family cultural capital on college students' major selection in China. Employing a mixed-methods approach, we analyzed data from a nationwide sample of 19,772 college students across various institution types.
View Article and Find Full Text PDFThe interplay between motor cost and self-efficacy related to walking across terrain in gaze and walking decisions.
Sci Rep
December 2024
Biomedical Physiology and Kinesiology, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
Motor behaviours, like where to step and which path to walk, rely on gaze shifts to gather visual information necessary to decide the next action. Factors influencing both gaze and walking decisions are poorly understood. Here we had people choose between two paths to determine how a person's belief in their ability to walk across different terrains (i.
View Article and Find Full Text PDFEvaluating and refining undersea cable path planning algorithms: A comparative study.
PLoS One
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Department of Electrical Engineering, City University of Hong Kong, Hong Kong SAR, China.
This paper compares three automated path-planning algorithms based on publicly available data. The algorithms include a Dijkstra-based algorithm (DBA) that improves on the straightforward application of Dijkstra's algorithm, which restricts the path only to the grid edges. We present a fair and comprehensive comparison method for evaluating multiple algorithms-DBA, the Fast Marching Method (FMM), and a great circle-based method.
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