We report the direct comparison of monomeric, dimeric and trimeric RBD protein subunit vaccines to a virus-like particle (VLP) displaying RBD. After two and three doses, a RBD dimer and trimer elicited antibody levels in mice comparable to an RBD-VLP. Furthermore, an Omicron (BA.1) RBD hetero-dimer induced neutralizing activity similar to the RBD-VLP. A RBD hetero-dimer and RBD-VLP also shows comparable breadth to other SARS-CoV-2 variants-of-concern (VOCs).
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168475 | PMC |
| http://dx.doi.org/10.21203/rs.3.rs-2692315/v1 | DOI Listing |
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