AI Article Synopsis
- - Action selection involves a competition between different choices, with neural activity observed in the frontal cortex and superior colliculus during these decisions.
- - Researchers found that specific cell types in the superior colliculus can influence choice competition and affect activity in the frontal cortex.
- - The study shows that distinct neuron types in both brain regions represent opposite choices and interact in a way that can enhance or suppress decision-making signals, highlighting the superior colliculus as a key player in choice-related actions.
Article Abstract
Action selection occurs through competition between potential choice options. Neural correlates of choice competition are observed across frontal cortex and downstream superior colliculus (SC) during decision-making, yet how these regions interact to mediate choice competition remains unresolved. Here we report that cell types within SC can bidirectionally modulate choice competition and drive choice activity in frontal cortex. In the mouse, topographically matched regions of frontal cortex and SC formed a descending motor pathway for directional licking and a re-entrant loop via the thalamus. During decision-making, distinct neuronal populations in both frontal cortex and SC encoded opposing lick directions and exhibited push-pull dynamics. SC GABAergic neurons encoded ipsilateral choice and glutamatergic neurons encoded contralateral choice, and activating or suppressing these cell types could bidirectionally drive push-pull choice activity in frontal cortex. These results thus identify SC as a major locus to modulate choice competition within the broader action selection network.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168218 | PMC |
| http://dx.doi.org/10.1101/2023.04.22.537884 | DOI Listing |
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