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Critical Insights into LEAP2 Biology and Physiological Functions: Potential Roles Beyond Ghrelin Antagonism.
Endocrinology
January 2025
Grupo de Neurofisiología- Instituto Multidisciplinario de Biología Celular (IMBICE) (Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de La Plata, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires), La Plata, Argentina.
Liver-expressed antimicrobial peptide 2 (LEAP2) has recently emerged as a novel hormone that reduces food intake and glycemia by acting through the growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor. This discovery has led to a fundamental reconceptualization of GHSR's functional dynamics, now understood to be under a dual and opposing regulation. LEAP2 exhibits several distinctive features.
View Article and Find Full Text PDFBisphenol A induces sex-dependent alterations in the neuroendocrine response of Djungarian hamsters to photoperiod.
Chemosphere
February 2025
Centre National de La Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 8 Allée Du Général Rouvillois, 67000, Strasbourg, France. Electronic address:
In nature, species synchronize reproduction and energy metabolism with seasons to optimize survival and growth. This study investigates the effect of oral exposure to bisphenol A (BPA) on phenotypic and neuroendocrine seasonal adaptations in the Djungarian hamster, which in contrast to conventional laboratory rodents, is a well-recognized seasonal model. Adult female and male hamsters were orally exposed to BPA (5, 50, or 500 μg/kg/d) or vehicle during a 10-week transition from a long (LP) to short (SP) photoperiod (winter transition) or vice versa (summer transition).
View Article and Find Full Text PDFFunctional foods with a tailored glycemic response based on food matrix and its interactions: Can it be a reality?
Food Chem X
June 2024
Division of Biochemistry, ICAR-Indian Agricultural Research Institute (IARI), New Delhi, India.
Functional foods are considered the future of nutrition because they benefit human health and environmental sustainability. They offer natural solutions for managing post-prandial glycemia and its long-term consequences. Therefore, understanding the composition and inherent dynamics of the functional food matrix (FM) is crucial.
View Article and Find Full Text PDFThe Predictive Role of Inflammatory Biomarkers and Their Correlation with the Biochemical Profile in Patients with Vasculopathy Undergoing Surgery.
Int J Mol Sci
November 2024
Department of Chemistry and Medical Biochemistry, Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureş, 540139 Targu Mures, Romania.
Article Synopsis
- * The study evaluated 62 patients (both diabetic and non-diabetic) undergoing lower limb surgeries, measuring various inflammatory and biochemical markers before and after the procedures.
- * Key findings showed correlations between specific markers (like IL-6 and TNF-α) and complications, indicating that monitoring these factors can help identify patients at higher risk and improve their management.
Survodutide for treatment of obesity: rationale and design of two randomized phase 3 clinical trials (SYNCHRONIZE™-1 and -2).
Obesity (Silver Spring)
January 2025
Section of Obesity Medicine and Center for Digestive Health, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Objective: The objective of this study was to describe the rationale and design of two multinational phase 3 clinical trials of survodutide, an investigational glucagon and glucagon-like peptide-1 receptor dual agonist for the treatment of obesity with or without type 2 diabetes (T2D; SYNCHRONIZE-1 and -2).
Methods: In these ongoing double-blind trials, participants were randomized to once-weekly subcutaneous injections of survodutide or placebo added to lifestyle modification. Survodutide doses are uptitrated to 3.
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