Four new iridoid glycosides (-), rehmaglutosides L-O, were isolated from the air-dried roots of . Their structures were established from the spectroscopic data obtained and by chemical evidence. The known mellittoside () and ajugol () were also obtained in the current investigation, and the structure of mellittoside was unequivocally defined using X-ray diffraction data. Compounds - were tested for their cytotoxicity against five human tumor cell lines and proliferation effects on .
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http://dx.doi.org/10.1080/10286020.2023.2202856 | DOI Listing |
Biotechnol Appl Biochem
December 2024
Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Targeting alpha-glucosidase (maltase-glucoamylase [MGAM] and sucrase-isomaltase [SI]) under diabetes conditions is important to overcome hyperglycemia. Moreover, it is necessary to mitigate hyperglycemia-mediated oxidative stress to evade the progression of diabetes-associated secondary complications. Hence, in the present study, under-explored Nyctanthes arbor-tristis flowers (NAFs) were studied for inhibition of alpha-glucosidase activities.
View Article and Find Full Text PDFMol Biol Rep
December 2024
Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Background: Oleuropein (OLE) has the potential to reduce oxidative stress and inflammation. So, in the present investigation, we explored the protective effect of OLE on brain aging induced by d-galactose (D-Gal) in a rat model.
Methods And Results: 40 Wister male adult rats were categorized into 5 groups.
Zhongguo Zhong Yao Za Zhi
November 2024
Wangjing Hospital of China Academy of Chinese Medical Sciences Beijing 100102, China Beijing Key Laboratory of Orthopaedic Technology of Traditional Chinese Medicine Beijing 100102, China.
This study aimed to investigate the effect of aucubin(AU) on injury of nucleus pulposus cells and extracellular matrix(ECM) degradation and its mechanism. The nucleus pulposus cell injury model was established by interleukin-1β(IL-1β) and treated with AU or phosphatidylinositol 3-kinase(PI3K) inhibitor LY294002. CCK-8 experiment was conducted to test cell proliferation.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
The hairy roots of (Gaertn.) Libosch. ex Fisch.
View Article and Find Full Text PDFNat Prod Res
December 2024
Unidad de Investigación Médica en Enfermedades Nefrológicas, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuauhtémoc, Mexico.
Three iridoid glycosides (mussaenoside, geniposide, and 5-hydroxy-8-epi-deoxyloganin) along with mannitol and acteoside, were isolated from , an endemic plant species of Mexico that currently belongs to the Orobanchaceae family. There is no information about the chemical composition of this species, consequently, the present work focuses on the chemical study of the flowers and leaves of , which were collected in two batches in Mexico, identifying the main components of each batch. The chemical structures were completely established by spectroscopic methods.
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