AI Article Synopsis
- Dengue is caused by four serotypes of the dengue virus (DENV-1 to -4), with DENV-4 being the least understood and often leading to complications like acute kidney injury in severe cases.
- This study aimed to explore how experimental infection with DENV-4 affects kidney tissue in adult BALB/c mice, using intravenous infection and subsequent analysis of the kidneys.
- Findings showed viral presence and significant kidney damage, including inflammation, glomerular enlargement, and necrosis of tubular cells, suggesting that while the kidney may not be a primary target for the virus, it still suffers damage from the infection.
Article Abstract
Background: Dengue is a disease caused by dengue virus (DENV-1 through -4). Among the four serotypes, DENV-4 remains the least studied. Acute kidney injury is a potential complication of dengue generally associated with severe dengue infection.
Objectives: The goal of this study was to investigate the alterations caused by experimental dengue infection in the kidney of adult BALB/c mice.
Methods: In this study, BALB/c mice were infected through the intravenous route with a DENV-4 strain, isolated from a human patient. The kidneys of the mice were procured and subject to histopathological and ultrastructural analysis.
Findings: The presence of the viral antigen was confirmed through immunohistochemistry. Analysis of tissue sections revealed the presence of inflammatory cell infiltrate throughout the parenchyma. Glomerular enlargement was a common find. Necrosis of tubular cells and haemorrhage were also observed. Analysis of the kidney on a transmission electron microscope allowed a closer look into the necrotic tubular cells, which presented nuclei with condensed chromatin, and loss of cytoplasm.
Main Conclusions: Even though the kidney is probably not a primary target of dengue infection in mice, the inoculation of the virus in the blood appears to damage the renal tissue through local inflammation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168658 | PMC |
| http://dx.doi.org/10.1590/0074-02760220255 | DOI Listing |
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