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Three new lanostane triterpenoids () along with two new amides fatty compounds () were isolated from the ethyl acetate extract of a culture of the endophytic fungus gx-2. Their structures were identified by 1D and 2D NMR spectral data and HRESIMS. Compounds were evaluated for their anti-inflammatory and tyrosinase inhibition activities. The isolated compounds did not show inhibitory activities at a concentration of 100 μM against tyrosinase, while under the concentration of 10 μM, the release of lactate dehydrogenase (LDH) inhibition rate of compound was 54.45%, indicating that compound had moderate anti-inflammatory activity on the activation of NLRP3 inflammasome.
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| http://dx.doi.org/10.1080/14786419.2023.2211215 | DOI Listing |
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