B cell-rich niches support stem-like CD8 T cells in cancer microenvironment.

Cancer Cell

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland. Electronic address:

Published: May 2023

AI Article Synopsis

  • Cytotoxic T cells play a crucial role in the immune response against various cancers.
  • A recent study by Gaglia et al. highlights how alterations in tumor tissue structure can create environments that enhance interactions between T cells and B cells.
  • These interactions may boost the effectiveness of T cell responses aimed at fighting tumors.

Article Abstract

Cytotoxic T cells are indispensable for the body's fight against most cancers. In the current issue of Cancer Cell, Gaglia et al. reveal how changes in the tumor tissue architecture creating niches of T cell-B cell interactions may support anti-tumor T cell responses.

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Source
http://dx.doi.org/10.1016/j.ccell.2023.04.007DOI Listing

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