is rare pathogen, and its pathogenicity to humans has been unknown. We describe an infant with bacteremia caused by . The patient was a 2-month-old girl presented with diarrhea, poor oral intake, and vomiting. The patient was tentatively diagnosed with acute enterocolitis. After admission, the patient developed a fever and blood culture yielded Gram-negative cocci, first determined to be by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. However, genetic analysis of 16S rRNA allowed its identification as (GenBank accession number is OQ547240). Other housekeeping genes such as , and also identified the isolated strain as . The patient was successfully treated with cefotaxime without sequelae. Later, the patient was diagnosed as non-IgE-mediated gastrointestinal food allergy. Our experience indicated that is a potential human pathogen that can cause invasive infections even in infants and children. Identification of is difficult with routine conventional tests, and detailed studies including genetic analyses are necessary to clarify the pathogenicity of in humans.
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http://dx.doi.org/10.2147/IDR.S402364 | DOI Listing |
Front Immunol
January 2025
Department of Hepatobiliary Surgery, Panzhihua Central Hospital, Sichuan, China.
This study aims to explore the pathogenic potential of as a rare pathogen in immunocompetent individuals and to analyze how mental health status may influence susceptibility to infection. We report a case of bacteremia in a 31-year-old immunocompetent female who developed infection during an episode of severe depression. Although the patient exhibited self-harm tendencies, a thorough physical examination did not reveal any external wounds or signs of injury.
View Article and Find Full Text PDFTunis Med
December 2024
Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco.
Zhonghua Xue Ye Xue Za Zhi
November 2024
Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
This study aimed to analyze the homology between carbapenem-resistant organisms (CRO) intestinal colonization strains and bloodstream infection (BSI) strains in patients undergoing hematopoietic stem cell transplantation (HSCT), confirming the clinical use of the real-time rectal swab Xpert Carba-R assay, and investigate its feasibility in early warning of BSI. Drug-resistant strains obtained from rectal swabs and blood culture samples of patients undergoing the same HSCT from January 2021 to December 2021 were collected and analyzed. The homology of the CRO intestinal colonization and BSI strains was confirmed using strain identification, antimicrobial resistance phenotyping, whole genome sequencing (WGS), multilocus sequence typing (MLST), and carbapenemase type identification.
View Article and Find Full Text PDFZhonghua Xue Ye Xue Za Zhi
November 2024
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Tianjin Institutes of Health Science, Tianjin 30l600, China.
This study aimed to analyze the clinical and molecular characteristics of carbapenem-resistant Enterobacteriaceae (CRE) bloodstream infection (BSI) in patients with hematological diseases and to explore prognostic risk factors. This retrospective study included patients with hematologic diseases with CRE BSI at the Institute of Hematology and Blood Diseases Hospital from January 2015 to December 2022. The clinical features, carbapenemase test results, antimicrobial treatments, and outcomes were analyzed.
View Article and Find Full Text PDFClin Microbiol Infect
December 2024
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia; School of Medicine and Public Health and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia.
Objectives: In this large retrospective cohort analysis, we aimed to determine the incidence of KDIGO-defined acute kidney injury (AKI) within 14 days in patients with Staphylococcus aureus bacteraemia, and the association of AKI with 30-day mortality.
Methods: A retrospective cohort study of adults with S. aureus bacteraemia between 1998 to 2023 admitted to a large regional Australian health service.
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