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The evolution of the discrete multirenculate kidney in mammals from ecological and molecular perspectives. | LitMetric

The evolution of the discrete multirenculate kidney in mammals from ecological and molecular perspectives.

Genome Biol Evol

Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China.

Published: May 2023

AI Article Synopsis

  • Mammals have developed different kidney shapes over time, and scientists are trying to understand how these changes happened and why.
  • They found that the simplest kidney type, called the unilobar kidney, is what all mammals originally had and that larger mammals or those living in water often have a more complex kidney called the discrete multirenculate kidney.
  • By studying 45 genes linked to kidney problems, researchers identified 12 important genes that might have helped these complex kidneys evolve, and they also found changes in some genes that are important for how certain body parts grow and develop.

Article Abstract

Mammals have developed different kinds of renal structures during evolution, yet the origin of the renal structural phenotypes and the molecular mechanisms underlying their adaptive evolution remains unclear. Here, we reconstructed the ancestral state of the renal structures across mammals and found that the unilobar kidney was the ancestral character in mammals. The subsequent correlation analyses between renal phenotypes and life history traits revealed that species with a larger body or in aquatic habitats tend to have evolved discrete multirenculate kidneys. To explore the molecular convergent mechanisms among mammals with this most distinct renal structure, the discrete multirenculate kidney, we used 45 genes related to duplex/multiplex kidney diseases to compare the evolutions of species with discrete multirenculate kidneys and with other renal phenotypes. Twelve rapidly evolving genes that were functionally enriched in cilium assembly and centrosome were identified in species with discrete multirenculate kidneys, suggesting that these genes played key roles in the evolution of discrete multirenculate kidneys. In addition, positive selection was detected in six crucial genes which are mainly involved in epithelial tube morphogenesis and regulation of neurogenesis. Finally, 12 convergent amino acid substitutions, six of which are in crucial domain of proteins, were shared by two or more lineages with discrete multirenculate kidneys. These findings could provide some novel insights into the origin and evolution of renal structures across mammals and the pathogenesis of renal diseases in humans.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198776PMC
http://dx.doi.org/10.1093/gbe/evad075DOI Listing

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