Laeviganoids A-T (-), 20 new -clerodane-type diterpenoids featuring a 2-furanone (-) or a furan (-) ring, as well as six analogues (-), were isolated from the roots of . Their structures were determined by spectroscopic data analysis, experimental electronic circular dichroism measurements, and X-ray crystallographic studies. Compounds -, , -, and could influence the anti-inflammatory protumoral phenotype of macrophages. Among these compounds, and are the most potent, as evidenced by consistently downregulating the classic anti-inflammatory cytokine IL-10 and upregulating the classic pro-inflammatory cytokine TNF-α on the secretion level in RAW 264.7 cells.
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Laeviganoids A-T, -Clerodane-Type Diterpenoids from .
J Nat Prod
May 2023
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
Laeviganoids A-T (-), 20 new -clerodane-type diterpenoids featuring a 2-furanone (-) or a furan (-) ring, as well as six analogues (-), were isolated from the roots of . Their structures were determined by spectroscopic data analysis, experimental electronic circular dichroism measurements, and X-ray crystallographic studies. Compounds -, , -, and could influence the anti-inflammatory protumoral phenotype of macrophages.
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