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The aging population presents critical challenges to global healthcare systems, with Japan expected to have 35% of its population aged 65 or older by 2040. Older adults often experience multimorbidity, cognitive impairments, and physical frailties, increasing healthcare utilization and costs. Traditional medical approaches that focus on organ-specific diagnoses are insufficient for addressing these multifaceted needs.
View Article and Find Full Text PDFBackground: The Detection of Indicators and Vulnerabilities for Emergency Room Trips (DIVERT) scale, the Community Assessment Risk Screen (CARS), and the Emergency Admission Risk Likelihood Index (EARLI) are scales that assess the risk of emergency department (ED) visits among home health care patients. This study validated these scales and explored factors that could improve their predictive accuracy among Japanese home health care patients.
Methods: This was a single-center retrospective cohort study.
Despite being increasingly adopted in various regions, the model of Hospital-at-home can still appear to be confusing to many healthcare workers. The authors examined and summarized the existing concepts and implementations of Hospital-at-home. How Hospital-at-home contrasts to traditional inpatient models were outlined.
View Article and Find Full Text PDFMolecular phylogeny and systematic revision of the Brazilian species of Pocock, 1894 (Arachnida: Uropygi: Mastigoproctinae).
Invertebr Syst
January 2025
Departamento de Zoologia, Instituto de Biociências, Universidade de São Paulo, Rua do Matão - travessa 14 #101, São Paulo, 05508-090, Brazil.
Uropygi is an order of arachnids commonly known as vinegaroons or whip-scorpions. So far, two genera are known to occur in Brazil: Thelyphonellus Pocock, 1894 and Mastigoproctus Pocock, 1894. We examined the morphology of 182 specimens of Brazilian Mastigoproctus and sequenced 42 specimens for phylogenetic analyses, using mitochondrial and nuclear molecular markers.
View Article and Find Full Text PDFPredictive Efficacy of Dual Therapies Combining Integrase Strand Transfer Inhibitors with Second-Generation Non-Nucleoside Reverse Transcriptase Inhibitors Following HIV-1 Treatment Failure in Cameroon: Implications for the Use of a Long-Acting Therapeutic Strategy in Low- and Middle-Income Countries.
Viruses
November 2024
Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.
Dual therapies (DT) combining integrase strand transfer inhibitors (INSTIs) with second-generation non-nucleoside reverse transcriptase inhibitors (2nd-Gen-NNRTIs) offer new possibilities for HIV treatment to improve adherence. However, drug resistance associated mutations (RAMs) to prior antiretrovirals may jeopardize the efficacy of DT. We herein describe the predicted efficacy of DT combining INSTIs + 2nd-Gen-NNRTI following treatment failure among Cameroonian patients.
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