Repair of peripheral nerves is recommended following transection. Systematic evaluation of longitudinal recovery in injury models is needed to improve patient management. Gompertz function provided straightforward interpretation and prediction of recovery outcomes. Behavioural sciatic function index, measured 3 days post injury, and weekly for 12 weeks following full nerve transection and repair (n = 6) as well as crush injuries (n = 6). Gompertz parametrization provided early classification between types of traumatic peripheral nerve injuries following surgical repair. Results distinguished injury nerves (A: p < 0.01; T: p < 0.05; Ic: p < 0.05 and outcome: p < 0.01). Early prognostication of outcomes (crush: 5.5 ± 0.3 and cut/repair: 8 ± 1 weeks) preceded current methods. Our findings identify injury type, state of recovery and early prognostication of outcome.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.2217/rme-2023-0011 | DOI Listing |
J Am Acad Orthop Surg
December 2024
From the Department of Orthopaedic Surgery, University of Utah, Salt Lake City, UT (Graesser), the Washington University School of Medicine in St. Louis, Mallinckrodt Institute of Radiology, St. Louis, MO (Parsons), and the Department of Orthopaedic Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO (Olafsen, Dy, and Brogan).
Traumatic peripheral nerve injuries represent a spectrum of conditions and remain challenging to diagnose and prognosticate. High-resolution ultrasonography and magnetic resonance neurography have emerged as useful diagnostic modalities in the evaluation of traumatic peripheral nerve and brachial plexus injuries. Ultrasonography is noninvasive, is able to rapidly interrogate large areas and multiple nerves, allows for a dynamic assessment of nerves and their surrounding anatomy, and is cost-effective.
View Article and Find Full Text PDFAnesthesiology
December 2024
In Residence, Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Background: Traumatic rib fractures are associated with pain lasting weeks to months and a decreased ability to inspire deeply or cough to clear secretions. Ultrasound-guided percutaneous cryoneurolysis involves reversibly ablating peripheral nerve(s) using exceptionally low temperature with a transdermal probe, resulting in a prolonged nerve block with a duration measured in months. We hypothesized that cryoneurolysis would improve analgesia and inspired volume following rib fracture.
View Article and Find Full Text PDFBone
December 2024
McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Department of Biomedical Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada; Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. Electronic address:
ACL injuries commonly lead to post-traumatic osteoarthritis (PTOA), but the underlying mechanism is not well-understood. One theorized mechanism is pathological bone remodelling following an ACL tear, for which high-resolution peripheral quantitative computed tomography (HR-pQCT) is uniquely positioned to investigate in vivo in humans. In this study, we longitudinally investigate the one-year changes in periarticular bone density and microarchitecture in the human knee following an ACL tear and reconstructive surgery using data sampled from an on-going observational cohort study.
View Article and Find Full Text PDFJ Hand Surg Glob Online
November 2024
Department of Orthopedic Surgery, Texas Tech University of Health Sciences Center, Lubbock, TX.
Purpose: In the adult literature, allograft reconstruction of gapped peripheral nerve injuries has gained popularity over autologous nerve grafting. Allografts have demonstrated similar recovery while eliminating donor site morbidity. There is no well-defined incidence or treatment of such injuries in children.
View Article and Find Full Text PDFPlast Reconstr Surg Glob Open
December 2024
From the Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Background: The goal of managing patients with peripheral nerve injuries is to improve how a patient feels and functions. This goal is best assessed with patient-reported outcome measures (PROMs), which elicit patient concerns, treatment goals, and clinical progression. This study reviews existing PROMs for adult patients with peripheral nerve injuries to assess how comprehensively they measure outcomes important to patients.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!