AI Article Synopsis
- Serotonin (5-HT) is linked to tumor growth and psychiatric disorders, and certain single-nucleotide variations (SNVs) in genes related to serotonin synthesis and receptors may affect 5-HT levels in oropharynx carcinoma (OPC).
- Analysis of DNA from 251 OPC patients and 254 controls revealed that the TPH1 TT variant was more common in patients, while HTR1D variants were associated with more aggressive tumors and shorter survival.
- The findings indicate that genetic variations in serotonin-related genes could potentially impact the development and progression of OPC, highlighting the need for further research in this area.
Article Abstract
Background: Serotonin (5-HT) is involved in regulating tumor growth, as well as psychiatric disorders. It is synthesized by tryptophan hydroxylase (TPH) and acts through 5-HT receptors (HTRs). Single-nucleotide variations (SNVs) in TPH1 rs623580 (T>A), TPH2 rs4570625 (G>T), and HTR1D rs674386 (G>A) may affect 5-HT levels. However, the effect of these SNVs on oropharynx carcinoma (OPC) is unknown.
Methods: DNA from 251 patients with OPC and 254 controls was analyzed by RT-PCR. Transcriptional activity of TPH1 rs623580 and HTR1D rs674386 was studied by luciferase assays. Multivariate statistical tests were utilized to evaluate group differences and survival outcomes.
Results: TPH1 TT was more frequent in patients than in controls (OR: 1.56, p = 0.03). Patients with HTR1D GG/GA showed invasive tumors (p = 0.01) and shorter survival (HR: 1.66, p = 0.04). TPH1 TT (0.79-fold, p = 0.03) and HTR1D GG (0.64-fold, p = 0.008) presented lower transcriptional activity.
Conclusion: Our data suggest that SNVs in 5-HT modulating genes can influence OPC.
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| http://dx.doi.org/10.1002/hed.27394 | DOI Listing |
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