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Evaluation of the anti-inflammatory activity of and identification of a new apigenin-3-- glycosylated type flavonoid. | LitMetric
Owing to the potentially harmful adverse effects of current anti-inflammatory drugs, there is a need to identify new alternative substances. Thus, this study aimed to perform a phytochemical analysis of to identify compounds responsible for its anti-inflammatory activity. Several fractions of the extract were obtained and evaluated in an anti-inflammatory assay using fresh human blood. Among the evaluated fractions, the BH fraction displayed the highest percentage of PGE inhibition (74.8%) compared to the reference drugs dexamethasone and indomethacin, demonstrating its excellent potential for anti-inflammatory activity. Astragalin (), a known 3--glucoside of kaempferol, was isolated from the extract for the first time. In addition, a new compound ( was isolated and identified as the apigenin-3--glycosylated flavonoid. Astragalin showed moderate PGE activity (48.3%), whereas was not anti-inflammatory. This study contributes to the phytochemical studies of and confirms its anti-inflammatory potential.
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