A scheme is presented to achieve quantum nonreciprocity by manipulating the statistical properties of the photons in a composite device consisting of a double-cavity optomechanical system with a spinning resonator and nonreciprocal coupling. It can be found that the photon blockade can emerge when the spinning device is driven from one side but not from the other side with the same driving amplitude. Under the weak driving limit, to achieve the perfect nonreciprocal photon blockade, two sets of optimal nonreciprocal coupling strengths are analytically obtained under different optical detunings based on the destructive quantum interference between different paths, which are in good agreement with the results obtained from numerical simulations. Moreover, the photon blockade exhibits thoroughly different behaviors as the nonreciprocal coupling is altered, and the perfect nonreciprocal photon blockade can be achieved even with weak nonlinear and linear couplings, which breaks the orthodox perception.
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http://dx.doi.org/10.1364/OE.486102 | DOI Listing |
J Control Release
December 2024
College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:
The interaction between programmed death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) constitutes a critical immune checkpoint pathway that leads to immune tolerance in cancer cells and impacts antitumor treatment. Monoclonal antibody blockade of the PD-L1 immunoinhibitory pathway has demonstrated significant and lasting clinical antitumor responses. Furthermore, PD-L1 serves as an important biomarker for predicting the effectiveness of immune checkpoint inhibitors (ICIs).
View Article and Find Full Text PDFBioconjug Chem
December 2024
Canary Center for Cancer Early Detection, Department of Radiology, Stanford University, Palo Alto, California 94304, United States.
The interaction between cancer cells and immune cells in the tumor microenvironment (TME) plays a crucial role in determining tumor growth, metastasis, and response to treatment. Tumor-infiltrating lymphocytes (TILs) in TME could be a predictive marker for treatment response in various therapeutic interventions, including chemotherapy and immunotherapy. Thus, imaging the tumor immune microenvironment is important for selecting the optimal treatment strategies in cancer therapy.
View Article and Find Full Text PDFMater Today Bio
December 2024
Key Laboratory of Molecular Cytogenetics and Genetic Breeding of Heilongjiang Province, College of Life Science and Technology, Harbin Normal University, Harbin, 150025, China.
Immunotherapy based on immune checkpoint blockade has emerged as a promising treatment strategy; however, the therapeutic efficacy is limited by the immunosuppressive microenvironment. Here, we developed a novel immune-activated nanoparticle (Fc-SS-Fe/Cu) to address the issue of insufficient immune infiltration. Specifically, the structure of Fc-SS-Fe/Cu collapsed in response to the tumor microenvironment, the ferrocene and disulfide bonds and the released Fe/Cu ions can effectively generate ·OH and deplete GSH to increase oxidative stress, thereby inducing ferroptosis.
View Article and Find Full Text PDFWe have achieved a conventional photon blockade and two-photon blockade in a second-order nonlinear system with a two-level atom embedded in a high-frequency cavity. The physical mechanisms behind the implementation of both types of photon blockade are explained, and analytical conditions for achieving a conventional photon blockade are derived, which are consistent with the numerical solutions of the master equation in the steady-state limit. By appropriately setting the system parameters, we can achieve simultaneous conventional photon blockade in the high-frequency cavity and two-photon blockade in the low-frequency cavity.
View Article and Find Full Text PDFWe propose a theoretical scheme for dipole exchange-induced grating (DEIG) based on a hybrid coherent atomic system. The system consists of an ultra-cold rubidium (Rb) atomic ensemble and movable Rydberg spin atoms. The optical response of the grating appears as a superposition of three- and four-level configurations, which is similar to the cooperative optical nonlinearity caused by the dipole blockade effect.
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