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Biomarkers.
Alzheimers Dement
December 2024
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Background: Vascular pathology associated with small vessel disease (SVD), such as microinfarcts and microbleeds, are common in elderly populations and significant contributors to cognitive impairment and dementia. Autosomal dominant cerebral arteriopathy with subcortical infarctions and leukoencephalopathy (CADASIL), caused by mutations in the Notch3 gene, is the most prominent inheritable SVD, with a common etiology of subcortical strokes and dementia. This study aimed to investigate additive or synergistic effects of CADASIL-related vascular alterations and familial Alzheimer's disease (FAD)-related amyloid pathology on cerebral metabolism of glucose and disease progression in a novel FAD-CADASIL mouse model.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Background: The method of obtaining pseudo-cerebral blood flow images from the initial minutes of amyloid PET scans has been proposed. This technique proves to be highly valuable as it not only indicates the presence of amyloid accumulation but also reveals sites of neurodegeneration. However, the obtained early images represent the K1 image rather than cerebral blood flow.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Background: Obesity and higher adiposity in midlife are recognized as contributors to Alzheimer disease (AD). Neurodegeneration in AD is at least partly mediated by vascular compromise and brain hypoperfusion. In this study, we aimed to investigate the associations between BMI and abdominal visceral and subcutaneous adipose tissue (VAT, SAT) and brain cerebral blood flow (CBF) in cognitively normal midlife individuals.
View Article and Find Full Text PDFBackground: We investigated the relationship between the cerebrospinal fluid (CSF) proteome in Alzheimer's disease (AD) and the clinical and biomarker-assisted diagnoses.
Methods: CSF was collected in 500 individuals of non-Hispanic white, African Americans, and Caribbean Hispanic individuals from Dominican Republic and New York City. CSF biomarkers of AD were measured including P-tau181, Aβ40, Aβ42, total-tau, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP).
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Alzheimers Dement
December 2024
IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Bologna, Italy.
Background: Cognitive decline in Alzheimer's disease (AD) continuum is knowingly associated with degenerative neurobiological features; however, reliable markers for the early detection of the preclinical stages of AD are not fully established. The main goal of this study was to track ongoing brain neurodegeneration across the AD continuum by combining neuropsychological data, brain MRI features, and plasmatic - brain-derived circulating cell-free DNA (b-cfDNA) biomarkers.
Method: A total of 91 participants were included in this study including 28 healthy controls (HC) (mean age 66.
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