AI Article Synopsis
- The study investigated the effect of inflating pressures (Pinfl) in infants under volume-targeted ventilation by analyzing data from 195 patients.
- It was found that periods of low Pinfl (below 5 mbar) occurred in 30% of infants and did not negatively impact blood gas levels, even though spontaneous breathing efforts increased.
- Low Pinfl was linked to similar tidal volumes and ventilation rates as higher Pinfl, indicating that low inflating pressure is common and can be safely tolerated in these infants.
Article Abstract
Objectives: We investigated the inflating pressures (Pinfl, the difference between peak inspiratory pressure and positive end-expiratory pressure) in infants receiving volume targeted ventilation.
Methods: Data were collected and analysed from 195 infants. Median Pinfl was determined before each blood gas (n = 3425). Ventilator parameters and blood gases were compared between periods when Pinfl was <5 mbar and periods when it was higher.
Results: 1-hour periods when median Pinfl was <5 mbar occurred in 30% of the babies and were associated with similar tidal volumes and minutes ventilation as periods with higher Pinfl. Babies triggered more ventilator inflations, had more spontaneous breaths and lower oxygen requirement when Pinfl was low. There was no difference in blood gases when Pinfl was <5 mbar or when it was higher.
Conclusions: Episodes of low inflating pressure occur frequently in babies receiving volume targeted ventilation, but they do not lead to changes in blood gases.
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| http://dx.doi.org/10.1038/s41372-023-01695-4 | DOI Listing |
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