AI Article Synopsis
- Alzheimer's disease affects around 6.5 million people aged 65+ in the U.S. and resveratrol may help combat it due to its biological properties.
- The research focused on developing an intranasal formulation of resveratrol using surfactant-based systems to improve its solubility, using ingredients like oleic acid and CETETH-20.
- Tests showed that this formulation effectively improved learning and memory in animals and reduced neuroinflammation, making it a promising treatment option for Alzheimer's.
Article Abstract
Alzheimer's disease (AD) is an illness that affects people aged 65 or older and affects around 6.5 million in the United States. Resveratrol is a chemical obtained from natural products and it exhibits biological activity based on inhibiting the formation, depolymerization of the amyloid, and decreasing neuroinflammation. Due to the insolubility of this compound; its incorporation in surfactant-based systems was proposed to design an intranasal formulation. A range of systems has been produced by mixing oleic acid, CETETH-20 and water. Polarised light microscopy (PLM), small angle x-ray scattering (SAXS) and transmission electron microscopy (TEM) confirm the initial liquid formulation (F) presented as microemulsion (ME). After dilution, the gelled systems were characterized as hexagonal mesophase and they showed feasibility proprieties. Pharmacological assays performed after intranasal administration showed the ability to improve learning and memory in animals, as well as remission of neuroinflammation via inhibition of interleukin.
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| http://dx.doi.org/10.1016/j.nano.2023.102689 | DOI Listing |
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