Patients prefer free drug disposal options delivered by pharmacists at the point of care: Results of a decision tree analysis of a national factorial vignette panel survey.

Int J Drug Policy

PREMIER Center, University of Houston, College of Pharmacy, Houston, TX, USA; Department of Pharmaceutical Health Outcomes and Policy, University of Houston College of Pharmacy, Houston, TX, USA; Prescription Drug Misuse Education and Research (PREMIER) Center, University of Houston College of Pharmacy, USA.

Published: June 2023

AI Article Synopsis

  • Unused opioid medications pose risks of misuse and harm, prompting the FDA to consider a REMS program for necessary drug disposal products.
  • A study used vignettes to evaluate consumer preferences for drug disposal options, considering factors like cost, ease of use, environmental impact, and access points.
  • Results indicated that free and easily accessible disposal methods, particularly pharmacy takeback programs, were most favored by participants, highlighting the importance of providing disposal resources with prescriptions.

Article Abstract

Background: Unused opioid medication in the home increases risk of medication diversion, misuse, and unintended harm. The United States Federal Food and Drug Administration is currently considering the implementation of a risk evaluation and mitigation strategy (REMS) program that would require US pharmacists to provide drug disposal products with opioid prescriptions. Still, little is known about consumer preference for drug disposal method. The objective of this study was to identify product and program characteristics associated with consumer preference for at-home drug disposal products.

Methods: A 2x2x3x3 full-factorial design was employed to text-based vignettes representing opioid analgesic disposal scenarios. Each vignette varied on four characteristics: product cost (free vs paid), ease of use (a mail back envelope, bringing medication to a takeback site, and an at-home drug deactivation pouch), potential environmental impact (incineration), and point of access (pharmacy, community organization, and prescriber). Of the 36 possible vignettes, 12 were removed as they represented a non-realistic combination of vignette characteristics. The remaining 24 were administered to a panel of patients with controlled-substance use in the past six-months. Decision tree modeling and general linear mixed (GLM) models were used sequentially to identify product characteristics associated with patient drug preferences RESULTS: A total of 1,006 participants completed all vignette drug disposal scenarios. Regression tree analysis found that the most important predictor of use was cost followed by ease of access and product design. GLM showed that takeback programs offered at a pharmacy were the most preferred disposal option followed by at-home products (mailed envelope or deactivation system) dispensed with the prescription.

Conclusion: Programs that provide disposal resources directly to the patient at no cost with their prescription are likely to optimize willingness to dispose. Findings support the FDA's plan for a REMS program requiring pharmacies to distribute mail-back envelopes to patients when dispensed opioids.

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Source
http://dx.doi.org/10.1016/j.drugpo.2023.104045DOI Listing

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