An ultra-thin multimode fiber is an ideal platform for minimally invasive microscopy with the advantages of a high density of modes, high spatial resolution, and a compact size. In practical applications, the probe needs to be long and flexible, which unfortunately destroys the imaging capabilities of a multimode fiber. In this work, we propose and experimentally demonstrate sub-diffraction imaging through a flexible probe based on a unique multicore-multimode fiber. A multicore part consists of 120 Fermat's spiral distributed single-mode cores. Each of the cores offers stable light delivery to the multimode part, which provides optimal structured light illumination for sub-diffraction imaging. As a result, perturbation-resilient fast sub-diffraction fiber imaging by computational compressive sensing is demonstrated.
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http://dx.doi.org/10.1364/OE.481052 | DOI Listing |
J Clin Oncol
January 2025
Institute of Cancer Research, London, United Kingdom.
Purpose: Transurethral resection of bladder tumor (TURBT) is the initial staging procedure for new bladder cancers (BCs). For muscle-invasive bladder cancers (MIBCs), TURBT may delay definitive treatment. We investigated whether definitive treatment can be expedited for MIBC using flexible cystoscopic biopsy and multiparametric magnetic resonance imaging (mpMRI) for initial staging.
View Article and Find Full Text PDFRadiol Case Rep
March 2025
Department of Otorhinolaryngology Head and Neck Surgery, Charles Nicolle Hospital, Tunis, Tunisia.
Tracheal adenoid cystic carcinoma is a rare malignancy. We report the case of a 65-year-old male who presented to our department due to a 3-month history of mild dysphagia without other associated symptoms. The neck, laryngeal, and hypopharyngeal examinations were normal.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Department of Electrical Engineering, City University of Hong Kong, Kowloon, Hong Kong, 999077, China.
Optical edge detection is a crucial optical analog computing method in fundamental artificial intelligence, machine vision, and image recognition, owing to its advantages of parallel processing, high computing speed, and low energy consumption. Field-of-view-tunable edge detection is particularly significant for detecting a broader range of objects, enhancing both practicality and flexibility. In this work, a novel approach-adaptive optical spatial differentiation is proposed for field-of-view-tunable edge detection.
View Article and Find Full Text PDFMatrix Biol
February 2025
Department of Physics, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada. Electronic address:
Advanced Glycation End Products (AGEs) are the end result of the irreversible, non-enzymatic glycation of proteins by reducing sugars. These chemical modifications accumulate with age and have been associated with various age-related and diabetic complications. AGEs predominantly accumulate on proteins with slow turnover rates, of which collagen is a prime example.
View Article and Find Full Text PDFBrief Bioinform
November 2024
Department of Biology, University at Albany, SUNY, 1400 Washington Ave, Albany, NY 12222, United States.
The accuracy of assigning fluorophore identity and abundance, known as spectral unmixing, in biological fluorescence microscopy images remains a significant challenge due to the substantial overlap in emission spectra among fluorophores. In traditional laser scanning confocal spectral microscopy, fluorophore information is acquired by recording emission spectra with a single combination of discrete excitation wavelengths. However, organic fluorophores possess characteristic excitation spectra in addition to their unique emission spectral signatures.
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