Thio(seleno)cyano-difluoroalkylation of Alkenes Using Visible-Light Photocatalysis.

Org Lett

New Drug Development Center (NDDC), Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), 80 Cheombok-ro, Dong-gu, Daegu 41061, Republic of Korea.

Published: May 2023

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Article Abstract

A mild and efficient three-component thio(seleno)cyano-difluoroalkylation of simple alkenes is demonstrated using an iridium(ruthenium) photocatalyst. This protocol provides a direct and regioselective installation of both C-S(Se)CN [thio(seleno)cyanation] and C-C (difluoroalkylation) bonds.

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http://dx.doi.org/10.1021/acs.orglett.3c01206DOI Listing

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