AI Article Synopsis
- Five isocoumarin derivatives were isolated from the culture extract of CPCC 400810, including three new compounds named aspermarolides A-C.
- The structures of the compounds were analyzed using spectroscopic techniques, with specific focus on determining double bond geometry and absolute configuration.
- None of the compounds demonstrated cytotoxic effects against the HepG2 and HeLa human cancer cell lines tested.
Article Abstract
Five isocoumarin derivatives including three new compounds, aspermarolides A-C (), and two known analogues, 8-methoxyldiaporthin () and diaporthin () were obtained from the culture extract of CPCC 400810. The structures of these compounds were elucidated by spectroscopic methods. The double bond geometry of and were assigned by the coupling constants. The absolute configuration of was determined by electronic circular dichroism experiment. All compounds showed no cytotoxic activities against the two human cancer cells HepG2 and Hela.
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| http://dx.doi.org/10.1080/14786419.2023.2209820 | DOI Listing |
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Two novel diketopiperazine dimers (1 and 2) and two new 4-hydroxyphenylacetates (5 and 6), along with two previously known diketopiperazine dimers were isolated from the culture of the endolichenic fungus Aspergillus sp. CPCC 400810. Their structures were determined through comprehensive spectroscopic analysis, including high-resolution electrospray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) data.
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Article Synopsis
- Five isocoumarin derivatives were isolated from the culture extract of CPCC 400810, including three new compounds named aspermarolides A-C.
- The structures of the compounds were analyzed using spectroscopic techniques, with specific focus on determining double bond geometry and absolute configuration.
- None of the compounds demonstrated cytotoxic effects against the HepG2 and HeLa human cancer cell lines tested.
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