HBV markers were tested in sera of patients with various clinical and serological states of HBV infection, including patients with delta-infection, and were compared to the detection of HBV-DNA in the sera by hybridization. The results show that high levels of HBV-DNA (much greater than 100 pg/0.1 ml) are mainly found in sera of patients with chronic hepatitis or in early sera of HBs antigen carriers, while 17 of 20 patients with undetectable or trace amounts of DNA in early sera exhibited a self-limiting hepatitis infection. This test system could be prognostic value.
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