Aim And Objective: Currently, the major priority in the field of nanotechnology or nanoscience is research and development at the atomic- or molecular-level sciences. Almost every aspects of human health, including pharmaceutical, clinical research and analysis, and supplemental immunological systems, are significantly impacted by it. Diverse dental applications to the realm of nanotechnology, which also reflect developments in material sciences, have given rise to the field of nanodentistry and nanocatalytic drug development, especially in oral nanozyme research and application. This review is aimed to provide readers an in-depth analysis of nanotechnology's characteristics, varied qualities, and applications toward dentistry.
Materials And Methods: A query was carried out in PubMed and Google Scholar databases for the articles published from 2007 to 2022 using the keywords/MESH term nanomaterials, dentistry, nanoenzymes, metals, and antibacterial activity. Data extraction and evidence synthesis have been performed by three researchers individually.
Results: A total of 901 articles have been extracted, out of which 108 have been removed due to repetitions and overlapping. After further screening following exclusion and inclusion criteria, 74 papers were considered to be pertinent and that primarily addressed dental nanotechnology were chosen. Further, the data havebeen extracted and interpreted for the review. The results of the review indicated that the development of multifunctional nanozymes has been continuously assessed in relation to oro-dental illnesses to show the significant impact that nanozymes have on oral health.
Conclusion: As evidenced by the obtained results, with the advent of ongoing breakthroughs in nanotechnology, dental care could be improved with advanced preventive measures.
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http://dx.doi.org/10.4103/jispcd.JISPCD_175_22 | DOI Listing |
BMC Oral Health
January 2025
Faculty of Dentistry, Department of Restorative Dentistry, Gazi University, Bişkek St. 1. St. Number: 8 Emek, Ankara, Turkey.
Background: Repairing composite resins is a less invasive alternative to complete restoration replacement. To achieve a successful bond between the existing and newly applied composite materials, various surface preparation methods, such as sandblasting and acid etching, have been explored. The aim of the study was to evaluate the effect of different surface treatments on the repair bond strength of a universal nanohybrid composite resin restorative material before and after thermal aging, by utilizing a micro-shear bond strength (µSBS) test.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Department of Endodontics, Faculty of Oral and Dental Medicine, Egyptian Russian University, Badr City, Egypt.
Background: Disinfection of the root canal system is a challenge to all clinicians, calcium hydroxide Ca(OH) one of the most popular intracanal medications used for this purpose, has some unwanted effects on dentine. This study aimed to investigate the antibiofilm effect of Nanochitosan (CSNPs) and Calcium hydroxide Ca(OH) intra canal medications and their effect on the microhardness and chemical structure of radicular dentine.
Methodology: A total of 52 extracted human mandibular premolars were used.
Clin Oral Investig
January 2025
Department of Dentistry, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Objectives: This study aimed to determine whether incorporating nanostructured additives into bleaching agents enhances efficacy and reduces side effects while identifying gaps for further investigation.
Methods: A comprehensive search was conducted in electronic databases, including PubMed/Medline, Embase, Scopus, and ISI Web of Science. Two reviewers independently screened articles based on predefined criteria, resolving discrepancies through discussion or consultation with a third reviewer.
J Neurochem
January 2025
Institute of Biostructures and Bioimaging, Italian National Council for Research (IBB-CNR), Naples, Italy.
The natural compound orotic acid and its anionic form, orotate, play a pivotal role in various biological processes, serving as essential intermediates in pyrimidine de novo synthesis, with demonstrated connections to dietary, supplement, and neurodrug applications. A novel perspective on biomolecular aggregation at the nanoscale, particularly pertinent to neurodegeneration, challenges the established paradigm positing that peptide (amyloid beta) and protein (tau) aggregation mainly govern the molecular events underlying prevalent neuropathologies. Emerging biological evidence indicates a notable role for G-quadruplex (G4) DNA aggregation in neurodegenerative processes affecting neuronal cells, particularly in the presence of extended (GC) repeats in nuclear DNA sequences.
View Article and Find Full Text PDFCancer Control
January 2025
Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia.
Background: Oral cancer remains 1 of the biggest health care challenges; it has a poor response to treatment, and treatment often results in severe side effects. Nano-targeted drug carrier-assisted drug delivery systems can improve the benefits of targeted drug delivery and treatment efficacy. A systematic review and meta-analysis was conducted to investigate the effect of targeted nano carrier drug delivery systems on the management of oral cancer.
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