AI Article Synopsis

  • - This study focused on Parkinson disease (PD), the second most common neurodegenerative disorder, and aimed to compare gene expression in blood versus brain tissue to identify potential targets for intervention.
  • - Researchers identified 540 differentially expressed genes (DEGs) in blood and 1024 in substantia nigra (SN) tissue from PD patients, revealing key functional pathways associated with the disease.
  • - A total of 13 DEGs showed similar expression patterns in both blood and SN, leading to the discovery of potential drug candidates that could serve as biomarkers or therapeutic targets for PD.

Article Abstract

The Parkinson disease (PD) is the second most common neurodegenerative disorder affecting the central nervous system and motor functions. The biological complexity of PD is yet to reveal potential targets for intervention or to slow the disease severity. Therefore, this study aimed to compare the fidelity of blood to substantia nigra (SN) tissue gene expression from PD patients to provide a systematic approach to predict role of the key genes of PD pathobiology. Differentially expressed genes (DEGs) from multiple microarray data sets of PD blood and SN tissue from GEO database are identified. Using the theoretical network approach and variety of bioinformatic tools, we prioritized the key genes from DEGs. A total of 540 and 1024 DEGs were identified in blood and SN tissue samples, respectively. Functional pathways closely related to PD such as ERK1 and ERK2 cascades, mitogen-activated protein kinase (MAPK) signaling, Wnt, nuclear factor-κB (NF-κB), and PI3K-Akt signaling were observed by enrichment analysis. Expression patterns of 13 DEGs were similar in both blood and SN tissues. Comprehensive network topological analysis and gene regulatory networks identified additional 10 DEGs functionally connected with molecular mechanisms of PD through the mammalian target of rapamycin (mTOR), autophagy, and AMP-activated protein kinase (AMPK) signaling pathways. Potential drug molecules were identified by chemical-protein network and drug prediction analysis. These potential candidates can be further validated in vitro/in vivo to be used as biomarkers and/or novel drug targets for the PD pathology and/or to arrest or delay the neurodegeneration over the years, respectively.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155030PMC
http://dx.doi.org/10.1177/11779322231166214DOI Listing

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