Introduction: Recent evidence suggests that the bone marrow (BM) plays a key role in the diffusion of malaria by providing a "niche" for the maturation of the parasite gametocytes, responsible for human-to-mosquito transmission. Suitable humanized models to study the mechanisms of the interplay between the parasite and the human BM components are still missing.
Methods: We report a novel experimental system based on the infusion of immature gametocytes into immunocompromised mice carrying chimeric ectopic ossicles whose stromal and bone compartments derive from human osteoprogenitor cells.
Results: We demonstrate that immature gametocytes home within minutes to the ossicles and reach the extravascular regions, where they are retained in contact with different human BM stromal cell types.
Discussion: Our model represents a powerful tool to study BM function and the interplay essential for parasite transmission in malaria and can be extended to study other infections in which the human BM plays a role.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154621 | PMC |
| http://dx.doi.org/10.3389/fcimb.2023.1161669 | DOI Listing |
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