The SARSCoV-2 virus, also known as the coronavirus-2, is the consequence of COVID-19, a severe acute respiratory syndrome. Droplets from an infectious individual are how the pathogen is transmitted from one individual to another and occasionally, these particles can contain toxic textures that could also serve as an entry point for the pathogen. We formed a discrete fractional-order COVID-19 framework for this investigation using information and inferences from Thailand. To combat the illnesses, the region has implemented mandatory vaccination, interpersonal stratification and mask distribution programs. As a result, we divided the vulnerable people into two groups: those who support the initiatives and those who do not take the influence regulations seriously. We analyze endemic problems and common data while demonstrating the threshold evolution defined by the fundamental reproductive quantity . Employing the mean general interval, we have evaluated the configuration value systems in our framework. Such a framework has been shown to be adaptable to changing pathogen populations over time. The Picard Lindelöf technique is applied to determine the existence-uniqueness of the solution for the proposed scheme. In light of the relationship between the and the consistency of the fixed points in this framework, several theoretical conclusions are made. Numerous numerical simulations are conducted to validate the outcome.
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http://dx.doi.org/10.1016/j.rinp.2023.106467 | DOI Listing |
Bioinformatics
January 2025
School of Artificial Intelligence, Jilin University, Jilin, China.
Motivation: Predicting RNA-binding proteins (RBPs) is central to understanding post-transcriptional regulatory mechanisms. Here, we introduce EnrichRBP, an automated and interpretable computational platform specifically designed for the comprehensive analysis of RBP interactions with RNA.
Results: EnrichRBP is a web service that enables researchers to develop original deep learning and machine learning architectures to explore the complex dynamics of RNA-binding proteins.
Psychol Aging
January 2025
Department of Psychology, National Taiwan University.
The Socioemotional Selectivity Theory (SST) posits that older and younger adults have different life goals due to differences in perceived remaining lifetime. Younger adults focus more on future-oriented knowledge exploration and forming new friendships, while older adults prioritize present-focused emotional regulation and maintaining close relationships. While previous research has found these age differences manifest in autobiographical textual expressions, their presence in verbal communication remains unexplored.
View Article and Find Full Text PDFElife
January 2025
Allen Discovery Center, Tufts University, Medford, United States.
Many applications in biomedicine and synthetic bioengineering rely on understanding, mapping, predicting, and controlling the complex behavior of chemical and genetic networks. The emerging field of diverse intelligence investigates the problem-solving capacities of unconventional agents. However, few quantitative tools exist for exploring the competencies of non-conventional systems.
View Article and Find Full Text PDFLab Chip
January 2025
CNRS UMR 7010, Institut de Physique de Nice (INPHYNI), Université Côte d'Azur, 06108 Nice, France.
pH regulation of eukaryotic cells is of crucial importance and influences different mechanisms including chemical kinetics, buffer effects, metabolic activity, membrane transport and cell shape parameters. In this study, we develop a microfluidic system to rapidly and precisely control a continuous flow of ionic chemical species to acutely challenge the intracellular pH regulation mechanisms and confront predictive models. We monitor the intracellular pH dynamics in real-time using pH-sensitive fluorescence imaging and establish a robust mathematical tool to translate the fluorescence signals to pH values.
View Article and Find Full Text PDFChembiochem
January 2025
Institute for Drug Discovery, University of Leipzig, Brüderstr. 34, 04103, Leipzig, Germany.
Recent advances in computational methods like AlphaFold have transformed structural biology, enabling accurate modeling of protein complexes and driving applications in drug discovery and protein engineering. However, predicting the structure of systems involving weak, transient, or dynamic interactions, or of complexes with disordered regions, remains challenging. Nuclear Magnetic Resonance (NMR) spectroscopy offers atomic-level insights into biomolecular complexes, even in weakly interacting and dynamic systems.
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