Purpose: The ongoing SARS-CoV-2 pandemic has resulted in over 6.3 million deaths and 560 million COVID-19 cases worldwide. Clinical management of hospitalized patients is complex due to the heterogeneous course of COVID-19. Low-dose radiation therapy is known to dampen localized chronic inflammation and has been suggested to be used to reduce lung inflammation in patients with COVID-19. However, it is unknown whether SARS-CoV-2 alters the radiation response and associated radiation exposure related risk.
Methods And Materials: We generated gene expression profiles from circulating leukocytes of hospitalized patients with COVID-19 and healthy donors.
Results: The signaling pathway was found to be dysregulated, with mRNA levels of , and being lower in patients with COVID-19. Several key target genes involved in cell cycle arrest, apoptosis, and feedback inhibition were upregulated in patients with COVID-19 while other target genes were downregulated. This dysregulation has functional consequences as the transcription of -dependant genes () was reduced 24 hours after x-ray exposure ex vivo to both low (100 mGy) or high (2 Gy) doses.
Conclusions: SARS-CoV-2 infection affects a DNA damage response that may modify radiation-induced health risks in exposed patients with COVID-19.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10039784 | PMC |
| http://dx.doi.org/10.1016/j.adro.2023.101215 | DOI Listing |
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