AI Article Synopsis
- The study aimed to identify clinical features, risk factors, and effective treatments for Carbapenem-resistant Acinetobacter baumannii (CRAB) bloodstream infections (BSI) based on data from a Chinese hospital.
- Among 276 patients, 157 had CRAB BSI, with key risk factors including ICU stays, immunocompromised status, and certain antibiotic use.
- The 30-day mortality rate for CRAB BSI was nearly 50%, with cefoperazone/sulbactam treatment showing a significant reduction in mortality compared to other antibiotic strategies.
Article Abstract
Objective: This study aimed to determine the clinical features, risk factors, and effective antimicrobial therapy for Carbapenem-resistant (CRAB) bloodstream infection (BSI).
Methods: This was a retrospective analysis of data from patients with CRAB bacteremia in a Chinese tertiary hospital between January 2012 and October 2021. Risk factors, predictors of 30-day mortality, and effective antimicrobial therapy for CRAB BSI were identified using logistic and cox regression analyses.
Results: Data from 276 patients with (AB) BSI were included, of whom 157 (56.9%) had CRAB BSI. The risk factors that were significantly associated with CRAB BSI included previous intensive care unit (ICU) stay ( < 0.001), immunocompromised status ( < 0.001), cephalosporin use ( = 0.014), and fluoroquinolone use ( = 0.007). The 30-day mortality of the CRAB BSI group was 49.7% (78/157). ICU stay after BSI ( = 0.047), sequential organ failure assessment (SOFA) score ≥10 ( < 0.001), and multiple organ failure (MOF) ( = 0.037) were independent predictors of 30-day mortality. Among antibiotic strategies for the treatment of patients with CRAB BSI, we found that definitive regimens containing cefoperazone/sulbactam were superior to those without cefoperazone/sulbactam in reducing the 30-day mortality rate (25.4% vs 53.4%, = 0.005). After propensity score matching, we observed a significant increase in the 30-day mortality (77.8%vs 33.3%, = 0.036) in patients receiving tigecycline monotherapy compared to those receiving cefoperazone/sulbactam monotherapy. The mortality rate of patients receiving tigecycline with cefoperazone/sulbactam was also higher than that of patients receiving cefoperazone-sulbactam monotherapy; however, the difference was not significant (28.6%vs 19.0%, = 0.375).
Conclusion: The severity of patient conditions was significantly associated with mortality in patients with CRAB BSI. Those Patients treated with cefoperazone/sulbactam had better clinical prognoses, and tigecycline should be used with caution.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154582 | PMC |
| http://dx.doi.org/10.2147/IDR.S408927 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Risk Factors for Development and Mortality of Bloodstream Infections Caused by Carbapenem-Resistant .
Infect Drug Resist
December 2024
Department of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Background: Bloodstream infections (BSIs) caused by (AB), especially carbapenem-resistant (CRAB), can lead to a high patient mortality rate.
Methods: This study aimed to analyze the clinical data and prognosis of 191 patients with AB-BSI hospitalized in Southern China from January 2017 to December 2023.
Results: CRAB was diagnosed in 128 (67.
The impact of the COVID-19 pandemic on hospital-acquired infections and multi-drug resistant organisms, in comparison to seasonal influenza.
BMC Infect Dis
November 2024
Infection Prevention and Control Unit, Rambam Health Care Campus, P.O. Box 9602, Haifa, 31096, Israel.
Background: While effective preventive measures reduce hospital-acquired infections (HAIs) and the spread of multi-drug resistant organisms (MDROs), studies on the impact of the COVID-19 pandemic and its associated preventive measures remain inconclusive.
Objective: To assess the impact of COVID-19 on HAIs and MDROs and to compare it with the effect of seasonal influenza.
Methods: A retrospective cohort study analyzed prospectively collected data from a tertiary hospital in Haifa, northern Israel, from 2016 to 2021.
Rectal colonization with multidrug-resistant organisms and risk for bloodstream infection among high-risk Greek patients.
Eur J Clin Microbiol Infect Dis
November 2024
Laboratory of Clinical Microbiology, School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Background: Studies link multidrug-resistant organism (MDRO) rectal colonization to increased infection risk, data from Greece, a country with high rates of MDRO, are limited.
Methods: We assessed bloodstream infection (BSI) risk following rectal colonization by MDROs across three Greek hospitals (2019-2022).
Results: Of 4,370 inpatients, 31.
Multidrug-resistant organism bloodstream infections in solid organ transplant recipients and impact on mortality: a systematic review.
JAC Antimicrob Resist
October 2024
Department of Infectious Diseases, The Alfred Hospital and School of Translational Medicine, Monash University, Melbourne, Australia.
Article Synopsis
- Bloodstream infections (BSIs) in solid organ transplant (SOT) recipients show high levels of multidrug-resistant organisms (MDROs), significantly impacting morbidity and mortality rates.
- A systematic review analyzed 52 studies, revealing that resistance percentages for MDROs like carbapenem-resistant Enterobacterales and MRSA varied geographically, with the highest rates found in Asia and North America.
- The crude mortality associated with MDRO BSIs ranged from 15.4% to 82.4%, indicating a critical need for more comprehensive research in this vulnerable patient population.
Comparison of Hypervirulent and Non-Hypervirulent Carbapenem-Resistant Isolated from Bloodstream Infections: Mortality, Potential Virulence Factors, and Combination Therapy In Vitro.
Antibiotics (Basel)
August 2024
State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China.
Article Synopsis
- Hypervirulent carbapenem-resistant * (hv-CRAB) strains have been linked to severe bloodstream infections (BSI) in hospitalized patients, posing a significant health threat.
- A study of 31 CRAB strains from Chinese patients found that those with hv-CRAB-BSI had much higher rates of septic shock (79.2%) and mortality (66.7%) compared to non-hv-CRAB-BSI strains.
- The research also revealed that while all strains were resistant to most antibiotics, they were sensitive to colistin, and a combination treatment of colistin and minocycline showed promise for effective management of these infections.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!