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| http://dx.doi.org/10.3988/jcn.2022.0472 | DOI Listing |
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Nanopore sequencing as a novel method of characterising anorexia nervosa risk loci.
BMC Genomics
December 2024
Pathology and Biomedical Science Department, University of Otago Christchurch, Christchurch, New Zealand.
Background: Anorexia nervosa (AN) is a polygenic, severe metabopsychiatric disorder with poorly understood aetiology. Eight significant loci have been identified by genome-wide association studies (GWAS) and single nucleotide polymorphism (SNP)-based heritability was estimated to be ~ 11-17, yet causal variants remain elusive. It is therefore important to define the full spectrum of genetic variants in the wider regions surrounding these significantly associated loci.
View Article and Find Full Text PDFImplementing an AI algorithm in the clinical setting: a case study for the accuracy paradox.
Eur Radiol
December 2024
Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Objectives: We report our experience implementing an algorithm for the detection of large vessel occlusion (LVO) for suspected stroke in the emergency setting, including its performance, and offer an explanation as to why it was poorly received by radiologists.
Materials And Methods: An algorithm was deployed in the emergency room at a single tertiary care hospital for the detection of LVO on CT angiography (CTA) between September 1st-27th, 2021. A retrospective analysis of the algorithm's accuracy was performed.
Unraveling the associations between voice pitch and major depressive disorder: a multisite genetic study.
Mol Psychiatry
December 2024
Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, University of California Los Angeles, Los Angeles, CA, USA.
Major depressive disorder (MDD) often goes undiagnosed due to the absence of clear biomarkers. We sought to identify voice biomarkers for MDD and separate biomarkers indicative of MDD predisposition from biomarkers reflecting current depressive symptoms. Using a two-stage meta-analytic design to remove confounds, we tested the association between features representing vocal pitch and MDD in a multisite case-control cohort study of Chinese women with recurrent depression.
View Article and Find Full Text PDFUnderstanding the coupled relationship between regional longevity and physical geographical environment in Hechi, Guangxi, China.
Sci Rep
December 2024
Department of Infrastructure, The University of Melbourne, Melbourne, Australia.
Healthy ageing plays an important role in ageing societies in many countries, and centenarians are a sign of longevity. Longevity and its determinants have become issues of global concern and also a focus of research. Although many disciplines have conducted out a series of studies on longevity phenomena, few studies have systematically considered the impact of geographical environmental factors.
View Article and Find Full Text PDFRisk Factors and Treatment Strategies for Anastomotic Ulcers in Pediatric Intestinal Failure.
J Pediatr Surg
December 2024
Department of Surgery, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address:
Purpose: Anastomotic ulcers (AUs) are a rare cause of morbidity in intestinal failure (IF). Prior studies of AUs have been small, descriptive reports. We evaluated a large cohort of IF patients to identify risk factors and describe treatment strategies for AUs.
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