AI Article Synopsis
- The study investigates end-of-life chemotherapy and targeted therapy in Japan using the DeSC database, focusing on the aggressiveness of care from 2015 to 2020.
- It analyzed 7,300 cancer-related deaths, finding that 11.6% of patients received anticancer drugs in their final 30 days, with S-1 monotherapy being the most common treatment.
- The results aim to enhance understanding and guide future research on improving the quality of life for patients with advanced cancer.
Article Abstract
Purpose: This study aimed to investigate the current status of end-of-life chemotherapy and targeted therapy and explore the aggressiveness of end-of-life care in Japan using the DeSC database, a large administrative claims database.
Methods: We identified fatal cases of at least one cancer-related diagnosis between April 2015 and November 2020. Patients prescribed at least one anticancer drug were analyzed, and chemotherapy regimens were categorized based on the combination of concomitant anticancer drugs prescribed.
Results: Among 1,095,713 individuals enrolled in the National Health Insurance database, 7,300 deaths with cancer-related diagnosis were identified. Of these, 4,010 cases were identified in which at least one anticancer drug was prescribed, and 11.6% of 7,300 death had been prescribed anticancer drugs in their last 30 days of life. The most commonly used regimen was S-1 (tegafur, gimeracil, and oteracil potassium combination) monotherapy, followed by nivolumab monotherapy and nab-paclitaxel plus gemcitabine. Immune checkpoint inhibitor monotherapy was more likely prescribed to patients whose last chemotherapy dose was in the last 30 days of life (p = 0.0066, chi-squared test).
Conclusions: This study provides insights into the current status of end-of-life chemotherapy and targeted therapy in Japan, using a large administrative claims database. The results of this study will inform future research on end-of-life chemotherapy and targeted therapy, and help develop strategies to improve the quality of life of patients with advanced cancer.
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| http://dx.doi.org/10.1007/s00280-023-04535-6 | DOI Listing |
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